Two best friends with Down Syndrome are ecstatic to discover that they have been selected to test Hoogle?s new technology: the Hoogle Hat. But when the hat seems to brainwash the other test subjects, they realize that they are the only people who can stop Hoogle from taking over the world.

Best to avoid unnecessary lengthy descriptions and overly wordy sentences in a logline. Get strait to the plot i.e:
A significant event happens to a main character, with a specific flaw, that must take action to achieve a clear objective goal.

How about this?

Two best friends with Down Syndrome learn they've been selected to participate in a controversial project that increases intelligence. But when the friends uncover that the doctor running the program is brainwashing his other test subjects, they must team-up using their new found intelligence to stop the doctor from enslaving the masses. Something like that.

You could explain the Hoogle Hat and who Dr. Hoogle is in your synopsis.

Hope this helps.

Okay very helpful again. How about this:

When a depressed young man with Down Syndrome meets someone online looking for subjects to test his ?cure? on, he enlists the help of his best friend to travel to Florida with the hopes of finding a cure.

In addition to DPGs comments, the inciting incident doesn't appear to have a direct impact on the protagonist (which ever character that ends up being).

A large company announces something is not an event or action done to the MC. A good inciting incident needs to provide a sudden change to the life and world of the MC and force him or her to pursue the goal. In this case the event seems incidental to the MC's life and their resulting actions come across as laboured and unrelated.

How can you directly relate the company's actions and MC to each other?

The logline presents 2 protagonists with 2 disparate goals. A logline ought to spotlight one character as the protagonist and state that protagonist's one objective goal. The other character would be a supporting character to the protagonist's objective goal.

So who is the protagonist? What is his singular objective goal? Who opposes him? And what are the stakes if he fails?

Okay these notes have been very helpful. Worked on it a bit more today with all of your notes in mind and this is what I came up with:

After a biotechnology company announces they will be testing a new form of gene therapy, two adversarial classmates team up in an attempt to be a part of the study: one with the hopes of curing his Down Syndrome and the other with the goal of exposing the company to the world as evil.

Thoughts??