A housewife and her estranged father mixed up in killing a loan shark struggle to escape both the police hunting them and a brothers vengeance to save the innocent members of their family.

Not too bad -- the main issue I think is in regards to the logic of the goal.. as in, why are they needing to save the innocent members of their family? Also - 'mixed up' is a bit vague, as is the Brother's need for vengeance..?

'A bored housewife finds herself on the run from the law after killing a loan shark to protect her estranged father-in-law'

?

Best of luck :)