Two women who had enough have to run from police when are involved in a killing incident. – Thelma and Louise

"When she kills the man attempting to rape her friend, a housewife and her gal pal make a run to Mexico in order to get away from the police, hot on their trail."

My take:

After a woman kills a man trying to rape her friend, a carefree weekend turns into a crime spree as the women race against the cops to the Mexican border.
(30 words)

Notes:
".... carefree weekend turns into a crime spree" highlights the ironic reversal of their original intention.
"they" -- because the story has dual protagonists.

fwiw

"When two male dominated women kill a rapist on their fishing trip, they go on a lawless spree while making a run for Mexico"

It doesn't completely work for some reasons
But I still wanted to discuss this film since it's one of my favourite screenplays. So jump in!